Nos dias 3 e 4 de outubro será ministrado no DQ-UFSCar o minicurso: “Process Chemistry in the Pharmaceutical Industry”, pela Dra. Helen Sneddon, GSK Scientific Team Director Medicinal Chemistry, Stevenage – UK. A inscrição é gratuita e aberta a todos os interessados e pode ser feita até o dia 27/09/19 pelo email: email@example.com
Programa do minicurso:
1st Day: Introduction to Process Chemistry
• overview of how it is structured – with particular reference to the GSK experience
• The varying role of Process Chemistry at different stages of Development
• The specific challenges of scale up
• The types of reactions done on scale
• Process Safety: Thermal decomposition data, reaction calorimetry (with case studies)
• Legal considerations – patent issues (with case study)
• Economic issues – with case study
• Control – with case studies (one about chocolate…one a more conventional chemistry story)
• The Green Chemistry Perspective
• Control in Process Development - Evolution of the Manufacturing Route to Vestipitant
2nd Day: Case studies
• 2,3-dihydrobenzofuran compounds for bromodomain inhibitors.
o a particular focus of the challenges of fluorination chemistry
o a gold mediated cyclisation
o an overview of flow chemistry…and the specific way it could mediate a safety concern for a high temperature Claisen rearrangement in this project
o the use of DoE…and its application in optimising an amino-carbonylation here.
• Sulfur Chemistry
o Development of a Solvent-Reagent Selection Guide for the Formation of Thioesters (and some challenges along the way)
o Sulfonylative couplings and the challenges of using SO2.